An extensive review of both human and animal studies published in Environmental Health, highlights growing evidence that synthetic food dyes—commonly used in processed foods and medications—may adversely affect children’s neurobehavioral health, particularly by exacerbating symptoms of Attention Deficit/Hyperactivity Disorder (ADHD).  

Analyzing 27 clinical trials, the California Office of Environmental Health Hazard Assessment (OEHHA) found that 64% showed associations between synthetic dye exposure and behavioral changes, with 52% reaching statistical significance. A meta-analysis estimated that about 8% of children might experience worsened ADHD symptoms due to these dyes. Animal toxicology studies further demonstrate behavioral and cognitive impairments at exposure levels near or below current FDA Acceptable Daily Intakes (ADIs), which were established without fully considering neurobehavioral outcomes. For example, exposures to Red No. 3 and Yellow No. 5 dyes have been linked to altered activity levels and disruptions in neurotransmitter systems, sometimes at doses ten times lower than existing safety thresholds. 

These findings underscore significant gaps in regulatory protections, especially for vulnerable populations like children, who often consume synthetic dyes at higher relative doses. The evidence calls for updated safety standards that incorporate neurodevelopmental risks and advocate for reduced use of synthetic dyes in food products. Organic agriculture provides a critical alternative by eliminating synthetic dyes altogether, promoting natural food ingredients that support neurodevelopmental health while advancing environmental sustainability. By choosing organic products, consumers reduce their exposure to potentially harmful additives, fostering healthier diets and aligning with broader goals to protect public health and the environment. This scientific evidence reinforces the importance of organic food systems as a proactive means to minimize chemical exposures, support safer food practices, and promote long-term wellbeing for children and families.